Tværfaglig/faglig organisation
Nationalt samarbejde mellem de eksperimentelle kræftbehandlingsenheder i Danmark, i regi af NEXT Centre for Onkologi og Hæmatologi. Nationalt samarbejde om bioinformatik og variant calling, netværk i DCCC og i NEXT center for Bioinformatik.

Projektbeskrivelse
Personlig medicin vinder hastigt indpas i kræftbehandling og nu kan danske kræftpatienter med udtømte behandlingsmuligheder få foretaget en kræft-genanalyse. Et nationalt panel af eksperter kan herefter anbefale patienten en eksperimentel behandling rettet mod bestemte genforandringer. Imidlertid mangler der stadig adgang til målrettede behandlinger og viden om, hvilke lægemidler der er mest effektive.
Vi påbegynder derfor en klinisk afprøvning af godkendte, målrettede behandlinger, hvor patienterne tilbydes en personlig behandling bestemt af resultatet af en kræft-genanalyse.

Primær kontaktperson
Morten Mau-Sørensen, paul.morten.mau-soerensen@regionh.dk

Deltagende parter
International collaborators
Emilie de Voest, NKI, PI of the Dutch Rediscovery Trial (DRUP)

Participants in the research project
University Hospital Rigshospitalet
Professor, Head of Department Ulrik Lassen; Department of Oncology
Chief Physician Kristoffer Rohrberg; The Phase I Unit, Department of Oncology
Senior Specialist Registrar Iben Spanggaard, The Phase I Unit, Department of Oncology
Chief Physician Martin Hutchings, The Phase I Unit, Department of Oncology and Department of Hematology
Professor, Head of Department Finn Cilius Nielsen; Department of Genomic Medicine
Head of the NGS facility Olga Østrup; Department of Genomic Medicine
Chief Physician Eric Santoni-Rugiu; Department of Pathology
Chief Physician Jane Preuss Hasselby; Department of Pathology

Aarhus University Hospital
Head of Research, Professor Signe Borgquist; Department of Oncology
Chief Physician Morten Ladekarl; Department of Oncology
Chief Physician Britt Elmedahl Laursen; MOMA
Associate Professor Nicolai Birkbak, MOMA
Professor Francesco d’Amore; Department of Hematology
Professor Torben Steinicke; Department of Pathology

Odense University Hospital
Professor Marianne Ewertz; Department of Oncology
Chief Physician, Head of Experimental Unit, Karin Holmskov Hansen; Department of Oncology
Senior Specialist Registrar Annette Raskov Kodahl; Department of Oncology
Professor Bjarne Winther Kristensen; Department of Pathology
Professor Thomas Kielsgaard Kristensen; Department of Pathology
Professor, Head of Research Henrik Ditzel; Department of Oncology
Professor Niels Abildgaard; Department of Hematology
Herlev-Gentofte University Hospital
Professor Dorte Nielsen; Department of Oncology
Senior Physician Rikke Eefsen; Department of Oncology
Professor Estrid Høgdahl; Department of Pathology

Lillebaelt Hospital, Vejle
Consultant, Ass. Professor Lars Henrik Jensen; Department of Oncology
Registrar Louise Raunkilde Larsen; Department of Oncology
Molecular Biologist Rikke Fredslund Andersen; Department of Clinical Biochemistry

Aalborg University Hospital
Professor Ursula Falkmer; Department of Oncology
Head of Department Paw Jensen; Department of Hematology
Associate professor, senior speciality registrar Anne Stidsholt Roug; Department of Hematology
Professor Karen Dybkær; Department of Hematology
Professor Martin Bøgsted; Department of Hematology