Grant received in 2021
DCCC has funded 200,000 DKKK to the preparation of this national and multidisciplinary investigator-initiated study.
Within the last few years, a clinical dilemma is seen with increasing frequency: What do we do, when an early colorectal cancer is accidentally removed by polypectomy? In other words, is supplementary (completion) resection necessary for cure – or is the patient already cured by the polypectomy itself?
Today, this is decided by examining the small tumor, and calculating a theoretical risk of residual disease based on the findings. Based on this, completion resection or just control is recommended. After completion resection, residual disease is found in only around 15 % of cases.
The funding from DCCC give the study an opportunity to prepare a study that examine, if circulating tumor DNA (ctDNA) can be measured in the patients with residual disease, whom thereby will benefit from completion resection – and correspondingly, if the absence of ctDNA can predict, if the patient is already cured. If so, it can spare many patients from potentially dangerous colorectal surgery.
Multidisciplinary organisation
DCCC Danish Research Centre for circulating tumor DNA guided treatment
Project stakeholders
- Mads Falk Klein, MD, PhD, Associate professor, Department of surgery, Copenhagen University Hospital Herlev. Primary contact, Mail: mads.klein@regionh.dk
- Jeppe Kildsig, MD, Department of surgery, Copenhagen University Hospital Herlev
- Kåre Gottschalk Sunesen, MD, PhD, Associate professor, Department of Surgery, Regional Hospital Randers
- Anne-Sofie Kannerup, MD, PhD, Head of Department, Department of Surgery, Regional Hospital Randers
- Lene Hjerrild Iversen, Professor, MD, DMSc, Department of Surgery, Aarhus University Hospital
- Claus Lindbjerg Andersen, Professor, Head of the ctDNA Research Center, Department of Molecular Medicine, Aarhus University
Hospital - Ismail Gögenur, Professor, MD, DMSc, Center for Surgical Science, Zealand University Hospital Køge
- Uffe Schou Løve, MD, Head of Research, Regional Hospital Viborg
- Per Vadgaard Andersen, MD, Specialist Consultant, Department of Surgery, Odense University Hospital
- Ole Thorlacius-Ussing, Professor, MD, DMSc, Department of Surgery, Aalborg University Hospital