Grant received in 2023.
DCCC has funded 200.000 DKK to the initiative.
Glioblastoma (GBM) is an incurable brain tumor with a median survival of 16-24 months. The current treatment for GBM consists of surgery followed by chemo- and radiotherapy The treatment effect is primarily evaluated clinically and and through the use of MRI scans. However, the current evaluation methods are not ideal for making clinical decisions.
Research conducted in various cancer types has shown a correlation between the presence of circulating tumour DNA (ctDNA) and the progression of cancer. This opens up an exciting opportunity to utilise ctDNA as a means to enhance the assessment of the treatment effect.
DCCC supports the planning of a national investigator initiated study focused on developing a specialised GBM panel using plasma samples. If the identification of ctDNA in plasma from GBM patients is successful, it has the potential to offer improved opportunities for assessing treatment effect and thereby establishing a more robust foundation for clinical decision-making.
By developing a targeted gene panel based on plasma from brain tumour patients, a promising approach to evaluating the treatment effect and identifying pseudoprogression in GBM patients emerges. This could enable more precise and individually tailored treatment, as well as better selection of patients for recurrence surgery or experimental treatment.
Multidisciplinary organisation
The study is anchored in the two national research centres, the DCCC-Brain Tumor Center and the DCCC Danish Reseach Centre for circulating tumor DNA guided treatment and includes all four centres that treat brain cancer in Denmark.
Project stakeholder
Oncology Odense
- Rikke Dahlrot, Medical Doctor, PhD
Oncology Aalborg
- Charlotte Aaquist Haslund, Medical Doctor
Molecular Midicine, MOMA Aarhus
- Lars Dyrskjøt, PhD., Professor
- Britt Elmedal, Medical Doctor, Associate Professor
Neurosurgery - Rigshospitalet
- Silas Haahr, Medical Doctor, PhD Student
Oncology Rigshospitalet
- Dorte Schou Nørøxe, Medical Doctor, PhD. Primary contact, e-mail: anne.dorte.schou.noeroexe@regionh.dk
- Hans Skovgaard Poulsen, Medical Doctor, Co-Director DCCC Brain Tumor Center
- Ulrik Lassen, Medical Doctor, Professor, Director DCCC Brain Tumor Center