Grant received in 2024.
DCCC has funded 200,000 DKK to the project.
The number of long-term survivors after thoracic cancer is increasing, and many of these patients have been treated with radiation therapy (RT). Unfortunately, some of these patients experience relapse or develop new cancerous growths near the previously irradiated area. Some of these patients may benefit from repeat radiation therapy (reRT) with a high radiation dose for curative purposes. However, there is a significant risk of severe side effects with reRT, as there are no established dose limits for normal tissue, and the literature in this area is limited to small studies. Additionally, combining two radiation doses is complex and uncertain.
This initiative aims to prepare a clinical trial where patients receiving reRT for lung tumors are registered. The purpose of the trial is to collect data on survival, side effects from both radiation treatments, and any systemic treatment. The group behind the application intends to develop safe methods for comparing and aggregating radiation doses.
Multidisciplinary organisation
The foundation of this initiative lies within the Danish Oncological Lung Cancer Group (DOLG). The development of the CURE Lung protocol involves cooperation among all 8 radiation therapy centers in Denmark.
Project stakeholders
Aalborg University Hospital
- Weronaika Maria Szejniuk (MD)
- Hella Maria Brøgger Sand (Physicist)
Aarhus University Hospital – Department of Oncology
- Marianne Marquard Knap (MD)
- Hjøedis Hjalting Schmidt (MD)
- Sine Overvad Fredslund (MD)
- Lone Hoffmann (Physicist). Primary contact, e-mail: Lone.Hoffmann@aarhus.rm.dk
Danish Centre for Particle Therapy
- Hanna Rahbek Mortensen (MD)
- Maria Fulsang Jensen (Physicist)
Vejle Hospital
- Torben Schjødt Hansen (MD)
- Mikkel Drøgemüller Lund (Physicist)
Odense University Hospital
- Tine Schytte (MD)
- Lotte Holm Land (MD)
- Morten Nielsen (Physicist)
Næstved Hospital
- Kenneth Francis Hofland (MD)
Herlev Hospital
- Gitte Persson (MD)
- Filippa Sundbye (MD)
- Katarina Wiviann Ottoson (Physicist)
Rigshospitalet
- Mette Pøhl (MD)
University of Leeds
- Ane Appelt (Physicist)