Grant received in 2023
DCCC has funded 200.000 DKK to the project.
Danish patients treated with chimeric antigen receptor T-cell (CART) therapies will be asked for consent to enrol prospectively in a database and provide blood samples at various time points during therapy.
The primary objective of the study is to compare outcomes for patients treated with CART therapies and to study long-term toxicities. Secondary objectives are investigations of outcomes after diff erent types of CART products, including hospital and commercially products. Biomarkers for response, toxicity, and CART persistence are studied using genetic profi ling on blood, tumor tissue, and pre-therapy imaging such as tumor volume. Blood will also be drawn for unspecifi ed future research.
The preparation of the study will include national meetings to agree on study design, case report forms, and logistics including development of redcap database, patient recruitment plans, additional funding applications, and biobank facilities.
Multidisciplinary organisation
Danish CAR-T cell Network (DCTN)
Project stakeholders
- Senior physician Søren Lykke Petersen, Hematology Department, Rigshospitalet
- Consultant Marianne RS Ifversen, Department of Pediatric Oncology, Rigshospitalet
- Senior physician Anne K Mylin, Hematology Department, Rigshospitalet
- Senior physician Eva Haastrup, Department of Immunology, Rigshospitalet
- Senior physician Bjarne K Møller, Department of Immunology, Aarhus University Hospital
- Senior physician Irma Petruskevicius, Department of Hematology, Aarhus University Hospital
- Senior physician Judit M Jørgensen, Hematology Department, Aarhus University Hospital
- Senior physician Henrik Frederiksen, Hematology Department, Odense University Hospital
- Senior physician Thomas S Larsen, Hematology Department, Odense University Hospital
- Senior physician Torben Barrington, Department of Immunology, Odense University Hospital
- Senior physician Christian Poulsen, Hematology Department, Zealand University Hospital
- Senior physician Thure Haunstrup, Department of Immunology, Aalborg University Hospital
- Senior physician Tarec El-Galaly, Hematology Department, Aalborg University Hospital
- Senior physician Brian Kornblit, Hematology Department, Rigshospitalet. Primary contact person, e-mail: brian.thomas.kornblit@regionh.dk