Grant received in 2021

DCCC has funded 177.000 DKK to the project

In recent years, research into the genome of cancerous tumors has led to the development of new targeted drugs against carcinogenic mutations. These drugs have improved survival in many cancers. Glioblastoma however, which is an incurable type of brain cancer, has not yet been able to take part in this development. The treatment and the median survival, of approx. 15 months, has been unchanged since 2005. The possible reasons for the missing development are many, including the fact that the performed clinical trials have not selected patients based on their individual mutations.

We therefore want to initiate a national clinical trial where, by using modern genomic analysis, we can identify patients' individual carcinogenic mutations and, based on those, select the targeted drug with the highest probability of increasing survival.

This trial will be a national translational collaboration between the country's leading genomic researchers and the 4 neuro oncological departments.

Multidisciplinary organisation

DCCC-Brain Tumor Center

Project stakeholders

  • Hans Skovgaard Poulsen, Consultant, Department of Oncology, Department of Neurosurgery, Rigshospitalet. Primary contact, Mail: hans.skovgaard.poulsen@regionh.dk 
  • Specialty registrar, PhD Slavca Lukacova, Department of Oncology, Århus University Hospital
  • Specialty registrar, PhD Rikke Dahlrot, Department of Oncology, Odense University Hospital
  • Consultant, Charlotte Aaquist Haslund, Department of Oncology, Ålborg University Hospital
  • Professor, PhD, consultant, Bjarne Winther Kristensen, Department of pathology, Rigshospitalet
  • Molecular biologist, PhD Olga Østrup, Genome medicine, Rigshospitalet
  • Group leader, Cand. Scient., PhD Joachim Weischenfeldt, Weischenfeldt Group, BRIC
  • Professor, PhD, head of department, Ulrik Lassen, DCCC-Brain Tumor Center, Rigshospitalet
  • Specialty registrar, PhD Benedikte Hasselbalch, DCCC-Brain Tumor Center, Rigshospitalet
  • Specialty registrar, Phd Thomas Urup, DCCC-Brain Tumor Center, Rigshospitalet
  • Medical doctor, PhD Dorte Nørøxe, DCCC-Brain Tumor Center, Rigshospitalet
  • Medical doctor, Vincent Fougner, DCCC-Brain Tumor Center, Rigshospitalet