Grant received in 2023
DCCC has funded 200.000 DKK to the project.
For about 15 percent of patients who are examined for recurrence of bowel cancer (stage II and III), it will not be possible for the doctors to determine whether there is a recurrence or not. At the same time, we know that the earlier a possible recurrence is detected, the better the prospects for subsequent treatment. But can circulating tumor DNA (ctDNA) be used to quickly and effectively discern whether an inconclusive CT scan should prompt further investigations?
If so, it can both reduce worry and the number of trips to the hospital for the patient - and save money for the healthcare system.
Therefore, DCCC supports the preparation of this study, which will partly investigate the extent to which inconclusive CT scan results delay diagnosis and treatment of recurrence for bowel cancer patients, and partly will investigate whether ctDNA can be used to provide fewer inconclusive results.
Multidisciplinary organisation
The DMCG Danish Colorectal Cancer Group (DCCG), DCCC Danish Research Centre for circulating tumor DNA guided treatment and Danish Center for Cancer Surgery - ACROBATIC
Project stakeholders
The DECIDE study is multidisciplinary with the participation of surgeons, radiologists, molecular medicine and health economists.
For the time being, the study is radiologically anchored at Aarhus University Hospital. Part of the preparation for the study is to extend the radiological participation to all Danish Regions.
DECIDE styregruppe:
- Postdoc Tenna Vesterman Henriksen, Dept. of Molecular Medicine, Aarhus University Hospital. Primary contact, e-mail: tvh@clin.au.dk
- Professor Claus Lindbjerg Andersen, Dept. of Molecular Medicine, Aarhus University Hospital, The Danish National Center for Circulating Tumor DNA Guided Cancer Treatment
- Consultant Sidse Bregendahl, Dept. of Radiology, Aarhus University Hospital
- Associated Professor, Consultant Kåre Andersson Gotschalck, Dept. of Surgery, Regional Hospital Horsens
- Associated professor, Consultant Liza Sophina, Danish Center for Health Economics (DACHE), University of Southern Denmark
Other active project stakeholders:
- Consultant Thomas Kolbro, Dept. of Surgery, Odense University Hospital - Svendborg
- Consultant Alessio Monti, Dept. of Surgery, Hjørring Hospital
- Consultant Jakob Lykke, Dept. of Surgery, Herlev Hospital
- Consultant Nis Hallundbæk Schlesinger, Dept. of Surgery, Copenhagen University Hospital, Bispebjerg
- Consultant Peter Bondeven, Dept. of Surgery, Regional Hospital Randers
- Professor, Consultant Lene Hjerrild Iversen, Dept. of Surgery, Aarhus University Hospital, Danish Research Center for Cancer Surgery (ACROBATIC)
- Professor, Consultant Ole Thorlassius-Ussing, Dept. of Surgery, Aalborg University Hospital
- Consultant Per Vadgaard Andersen, Dept. of Surgery, Odense University Hospital - Odense
- Associated Professor, Consultant Anders Husted Madsen, Dept. of Surgery, Regional Hospital, Gødstrup
- Head of Department, Consultant Uff e Schou Løve, Dept. of Surgery, Regional Hospital, Viborg
- Professor, Consultant Ismail Gögenur, Center for Surgical Science, Zealand University Hospital (Køge, Slagelse and Roskilde hospitals)
- Consultant Camilla Qvortrup, Dept. of Oncology, Rigshospitalet