Grant received in 2024.
DCCC has funded 150,000 DKK to the project.
Sino-nasal cancer is a rare disease with approximately 40 cases per year in Denmark. The disease has a grave prognosis and significant late side effects. The standard treatment consists of surgery and radiation therapy, either separately or in combination. Proton beam therapy is a possible treatment method that could potentially target the cancerous tumor more precisely with radiation while reducing the dose to the surrounding healthy organs.
This initiative has been given the opportunity to participate in a British study called PROTIS - a phase III trial comparing proton beam therapy to intensity-modulated radiation therapy for the treatment of sino-nasal cancer. The study will randomize patients to receive either proton beam therapy or conventional radiation therapy and is expected to include 276 patients over a period of 3 years. In addition to assessing tumor control, the study will also investigate the long-term effects of the treatment.
Participation in PROTIS is anticipated to yield several professional benefits, notably a substantial enhancement in treatment alternatives and the quality of life for patients.
Multidisciplinary organisation
This initiative is anchored in the the Danish Head and Neck cancer Study Group (DAHANCA).
Project stakeholders
- Dorte Winther, Leader, Danish Center for Particle Therapy, Aarhus University Hospital
- Hanna Primdahl, Oncologist, Department of Oncology, Aarhus University Hospital
- Jørgen Johansen, Oncologist, Department of Oncology, Odense University Hospital
- Mogens Bernsdorf, Oncologist, Department of Oncology, Rigshospitalet
- Maria Andersen, Oncologist, Department of Oncology, Aalborg University Hospital
- Christan Maare, Oncologist, Department of Oncology, Herlev Hospital
- Niclas Rubek, Surgeon, Department of Otorhinolaryngology, Head and Neck Surgery & Audiology, Rigshospitalet
- Kristian Bruun, Surgeon, Department of Otorhinolaryngology, Aarhus University Hospital
- Kristine Bjørndal, Surgeon, Department of Otorhinology, Odense University Hospital
- Caroline Olsen, Pathologist, Department of Pathology, Rigshospitalet
- Cai Grau, Professor, Head of research, Danish Center for Particle Therapy, Aarhus University Hospital
- Kenneth Jensen, Oncologist, Danish Center for Particle Therapy, Aarhus University Hospital. Primary contact, e-mail: kennjens@rm.dk