Grant received in 2021
DCCC has funded 200.000 DKK to the project
Patients diagnosed with glioblastoma (GBM), the most aggressive and most frequent form of brain cancer, are faced with a very poor prognosis. Radiotherapy (RT) is, together with surgery, the cornerstone of treatment. RT is however still similar for the vast majority of patients, while it is more and more recognised that GBM is a very heterogeneous disease, also reflected by large clinical differences between patients. Personalising RT to the individual patient is thus expected to improve patient outcomes tremendously. This national project aims to personalise the current 'one-size-fits-all' RT target. Artificial Intelligence will be used to personalise the target based on patient, tumour (including (epi)genetic markers), and treatment parameters, and advanced imaging. The resulting personalised target is crucial for further personalisation of RT dose intensification and modality (protons), which are complementing much needed strategies to improve the outlook of GBM patients.
Multidisciplinary organisation
Danish Neuro-oncology group, DCCC BTC
Project stakeholders
- Trine Guldberg, PhD, Specialty Registrar, Department of Oncology, Ålborg University Hospital
- Slavka Lukacova, PhD, Specialty Registrar, Department of Oncology, Århus University Hospital
- Aida Muhic, consultant, Department of Oncology, Rigshospitalet
- Anouk Trip, PhD, Specialty Registrar, The Danish Centre for Particle Therapy. Primary contact, Mail: anotri@rm.dk
- Jesper Kallehauge, PhD, Associate professor, medical physicist, The Danish Centre for Particle Therapy
- Morten Hoyer, PhD, Professor, Medical Director, The Danish Centre for Particle Therapy
- Rikke Dahlrot, PhD, Associate professor, Specialty Registrar, Department of Oncology, Odense University Hospital