Grant received in 2021

DCCC has funded 145.000 DKK to the project

Neoadjuvant immune therapy has shown promising effects on patients with deficient mismatch repair (dMMR) colorectal cancer (CRC). With support from DCCC, we will prepare two national multidisciplinary investigator-initiated multicenter studies to investigate 1) the effect of neoadjuvant immune therapy with Pembrolizumab to patients with dMMR colon cancer and 2) the effect of treatment with ipilimumab and nivolumab to patients with dMMR rectum cancer. The studies involve radiologists, surgeons/endoscopists and oncologists. To obtain the highest possible national participation, and high protocol compliance, it is important to present the protocols for the investigators.

The grant will be used to conduct 2 workshops: 1) to present the protocols and the financial structure, 2) to teach the sites in response evaluation to be able to achieve study standardization and uniform data. We also apply for 1 months VIP salary to prepare the workshops and to finalize the protocols for submission.

Multidisciplinary organisation

The study group is anchored in Danish Colorectal Cancer Group (DCCG). Commitments have been obtained from all 5 regions. The studies are expected to be approved by DCCG as a multidisciplinary multicenter study.

Project stakeholders

Zealand University Hospital

• Professor, Consultant Ismail Gögenur, Dept. of Surgery. Primary contact, e-mail: igo@regionsjaelland.dk
• Consultant, Mustafa Bulut, Dept. of Surgery
• Consultant, Anne-Marie Kanstrup Fiehn, Dept. of Pathology
• Post doc., Paulo Urbano, Dept. of Surgery
• Consultant, Peter Clausager Petersen, Dept. of Oncology 
• Consultant, Lars Simon Reiter, Dept. of Oncology
• Consultant, Hans Raskov, Dept. of Surgery
• Medical Doctor, Tobias Freyberg Justesen, Dept. of Surgery, Rigshospitalet
• Consultant, Camilla Qvortrup, Dept. of Oncology

Odense University Hospital

• Professor, Consultant, Per Pfeiffer, Dept. of Oncology
• Consultant, Søren Salomon, Dept. of Surgery
• Medical Doctor, Line Schmidt Tarpgaard, Dept. of Oncology

Aarhus University Hospital

• Professor, Claus Lindbjerg Andersen, Depart. of Molecular Medicine

Aalborg University Hospital

• Consultant, Michael Bødker Lauritzen, Depart. of Gastrointestinal Surgery
• Consultant, Ole Thorlacius-Ussing, Depart. of Gastrointestinal Surgery
• Medical Doctor, PhD, Laurids Østergaard Poulsen, Dept. of Oncology

Bispebjerg Hospital:

• Consultant Peter-Martin Krarup, Abdominal center K
• Consultant, Laura Buskov, Depart. of Radiology

Herlev og Gentofte Hospital:

• Consultant, Jakob Lykke, Dept. of Surgery
• Consultant, Jakob Schou, Dept. of Oncology