Grant received in 2023
DCCC has funded 200.000 DKK to the project.
With RESPONSE, a new follow-up program will be developed and tested for patients operated on for colon and rectal cancer, stage I and II. The current program focuses one-sidedly on relapse, which only 5-12% get. In contrast, 30-50% experience moderate-severe psychological/physical late effects.
By using circulating cancer cell DNA (ct-DNA) as a marker for recurrence instead of CT scans, it will be possible to free up resources for monitoring and treating late sequelae. The entire follow-up program and monitoring must be controlled by the patient himself from a smartphone app, in order to increase patient autonomy.
It is expected that the holistic, patient-directed follow-up program will improve the quality of life compared to the current program, without reducing survival or increasing costs.
Multidisciplinary organisation
The Steering Commitess is anchored in DCCC. The study group includes representatives from 4 of DCCC's national centres: DCCC Danish Research Centre for circulating tumor DNA guided treatment, Danish Center for Cancer Surgery (ACROBATIC), Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, National Center for Breast Cancer Survivorship
Project stakeholders
Steering committee:
- MD Ph.D. Mai-Britt Worm Ørntoft, Dept. of Molecular Medicine, Aarhus University Hospital. Primary contact, e-mail: mwo@clin.au.dk
- Professor Claus Lindbjerg Andersen, Dept. of Molecular Medicine, Aarhus University Hospital, The Danish National Center for Circulating Tumor DNA Guided Cancer Treatment
- Professor Lene Hjerrild Iversen, Dept. of Surgery, Aarhus University Hospital, Danish Research Center for Cancer Surgery (ACROBATIC)
- Professor Peter Christensen, Dept. of Surgery, Aarhus University Hospital, Centre for Research on Survivorship and Late Adverse Eff ects after Cancer in the Pelvic Organs
- Professor Ole Thorlacius-Ussing, Dept. of Surgery, Aalborg University Hospital
- Professor Robert (Bobby) Zachariae, Dept. of Onco-psychology, Aarhus University, Danish Breast Cancer Group Center & Clinic for Late Eff ects (DCCL)
- Ass. professor Liza Sopina, Danish Center for Health Economics, DaCHE, University of Southern Denmark
Representation from the recruiting departments:
- Professor Lene Hjerrild Iversen, Dept. of Surgery, Aarhus University Hospital
- Professor, Consultant Ole Thorlacius-Ussing, Dept. of Surgery, Aalborg University Hospital
- Head of Dept., Consultant Uff e Schou Løve, Dept. of Surgery, Region Hospital, Viborg
- Ass. Professor, Consultant Anders Husted Madsen, Dept. of Surgery, Region Hospital, Gødstrup
- Head of dept., Consultant Anne-Sofi e Kannerup, Dept. of Surgery, Region Hospital Randers
- Consultant Per Vadgaard Andersen, Dept. of Surgery, Odense University Hospital and Svendborg Hospital
- Consultant Mads Klein, Dept. of Surgery, Herlev Hospital
- Consultant Nis H. Schlesinger, Dept. of Surgery, Bispebjerg Hospital
- Ass. Professor, Consultant Kåre Gotschalck Sunesen, Dept. of Surgery, Regional Hospital, Horsens
- Consultant Camilla Qvortrup, Department of Oncology, Rigshospitalet